Which of the following indicates a therapeutic response to coagulation-modifying drugs?

A therapeutic response to coagulation-modifying drugs is indicated by improved circulation. When these medications are effective, they facilitate proper blood flow through the vascular system, enhancing the delivery of oxygen and nutrients to tissues. Improved circulation is crucial, especially in conditions where clotting issues may impair blood flow, leading to potential complications like ischemia.

In contrast, worsened tissue perfusion would suggest that the drug is not working effectively, potentially leading to adverse outcomes. An increased heart rate might occur as a compensatory mechanism in response to poor perfusion or low blood volume, while increased blood pressure does not directly correlate with the effectiveness of coagulation-modifying drugs since it can be influenced by numerous other factors such as volume status and systemic vascular resistance. Therefore, the most direct indicator of a successful therapeutic response in the context of coagulation is the improvement in circulation.