What role does plasmin play in the coagulation process?

Plasmin plays a critical role in the dissolution of blood clots, a process known as fibrinolysis. After a clot forms to stop bleeding, it is essential for the body to eventually break down the clot to restore normal blood flow and allow healing to proceed. Plasminogen, which is incorporated into the clot, is converted into plasmin through the action of various plasminogen activators, such as tissue plasminogen activator (tPA). Once activated, plasmin acts enzymatically to degrade fibrin, the primary structural component of blood clots, leading to the breakdown of the clot and the clearing of the blocked vessel.

This function is vital for maintaining a balance within the hemostatic system, ensuring that clots do not persist longer than necessary. The degradation of fibrin by plasmin contributes to the regulation of clotting processes, preventing excessive clot formation that could lead to complications such as thrombosis.