What is the significance of D-dimer testing in clotting disorders?

D-dimer testing plays a critical role in the evaluation of thrombotic events. It measures the presence of fibrin degradation products in the blood, which are generated when clots dissolve. A positive D-dimer test typically suggests an ongoing process of fibrinolysis, which often occurs in the setting of thrombosis. Elevated levels of D-dimer are associated with various conditions, including deep vein thrombosis (DVT) and pulmonary embolism (PE), making it a valuable tool in diagnosing these conditions.

The primary relevance of this finding is that it aids healthcare professionals in identifying patients who may need further imaging studies or treatment for thrombotic disorders. While a positive D-dimer test is not definitive for thrombosis (as false positives can occur due to other conditions), it is an important initial diagnostic step when assessing the likelihood of clotting disorders.