What does acetylsalicylic acid irrevocably prevent in platelets?

Acetylsalicylic acid, more commonly known as aspirin, acts on platelets by irreversibly inhibiting cyclooxygenase (COX) enzymes, particularly COX-1. This inhibition prevents the regeneration of thromboxane A2, a critical enzyme necessary for platelet activation and aggregation. By blocking this enzyme, aspirin effectively reduces the platelets' ability to aggregate and form clots. This mechanism underscores the cardiovascular protective effects of aspirin, as it helps to prevent unwanted thrombus formation that can lead to heart attacks or strokes.

In contrast, the other choices do not accurately reflect the specific action of acetylsalicylic acid on platelets. For instance, it does not affect white blood cell production, nor does it directly interfere with platelet adhesion to blood vessel walls or the release of clotting factors. The primary focus of acetylsalicylic acid's action is its impact on the regeneration of the enzyme involved in platelet aggregation.