In which disease is increased fibrinolytic activity commonly seen?

Increased fibrinolytic activity is commonly associated with severe infections or sepsis due to the body's response to systemic infection. During sepsis, the immune system is activated to fight off pathogens, leading to a cascade of inflammatory responses. This includes the activation of coagulation pathways as well as fibrinolysis, which is the process that breaks down fibrin in blood clots.

In severe infections, particularly sepsis, there is often an imbalance between coagulation and fibrinolysis that can contribute to disseminated intravascular coagulation (DIC). In this condition, there is increased fibrin formation and subsequent fibrinolysis, leading to elevated levels of fibrin degradation products and enhanced fibrinolytic activity.

The other conditions listed may have an impact on the coagulation cascade, but they do not universally exhibit the same marked increase in fibrinolytic activity as seen in severe infections or sepsis. In chronic kidney disease, there may be impaired fibrinolysis. Cancer can lead to a hypercoagulable state but does not specifically equate to increased fibrinolysis across the board. Diabetes mellitus is also associated with vascular issues but does not directly relate to heightened fibrinolytic activity in the same way as sepsis.